?? ?????? ?????? ???? ???? ???????? ???????? ????????? ?????? ?? ????? ?????? ?? ??? ??????. ??? ??? 2025? ?????? ??? ????? ?????? ?????? ??? ?? ?????. ?????? ?? ??? ??? ???????? ?????????? ?????????? ?????? ???????? ???????? ????????? ????? ????? ???????? ?????? ???????? ?? ?????? ?? ????? ????? ??????????? ??????? ?? ????? ???? ??????? ???????? ????? ?????? ??????? ????? ???? ?? ?? ???????? ?????? ?? ?????? ??????? ???????.
??? ???? ??????? ??????? ???????? ??? ???? ????? ?? ??????? ?????? ?????? ?????? ??????????? ?????? ???? ??????? ???????? ??? ?????? ???? ????????? ????? ??????? ???????? ??????? ?? ???? ????? ??????? ???????? ?????????? ????????? ?? ???????. ??? ??????? ???????? ????????? ?????? ?? ????? ??????? ?????????? ????????? ??? ??????? ???????? ?? ????? ???????????? ???? ??????? ????? ????? ??????? ?????? ????? ???????? ?????? ?????? ?????? ????? ??? ????? ?????? ???? ?????.
???? ?? ???? ??????? ?? ????? ?????? ??????? ?????? ?????? ????????? ??????? ?? ???? ??????? ??????? ?? ??????? ?????? ?????? ?????? ???????????? ???? ?????? ?? ??? ??????? ???????????? ??????? ?????? ???? ??????? ???????? ?????? ?????? ?????? ?????? ??? ????? ???????? ???????? ????????? ??? ???????? ???????? ??????? ???????? ??? ???????.
???? ??? ??????? ??????? ??? ????? ????? ????? ????? ?? ???? ??? ????? ?????? ?????? ???????? ???????? ??? ??????? ?????? ?????? ?? ?????? ??? ??????? ???????. ??? ?????? ????? ????? ?????? ?????? ?? ????? ????? ??????? ???????? ?? ?????? ??????? ???????. ???? ??????? ?????? ???????? ????? ?????? ?????? ????????.
???? ???? ????? ?? ????? ???????? ???????? ???? ????? ?????? ???? ??? ??????.
??????? ????? ??? ??????? ???? ????? ??????? ?????? ?????? ????????? ?????? ?? ???? ??? ?????? ?????? ??????. ???? ????? ?????? ??????? ??? ???? ?? ????? ?????????? ?????????? ???? ????? ??????????? ?? ??? ?? ??????? ?????? ???????.
??? ?????? ???????? ??????? ????????? ?????? ????????? ??????. ??????? ??????? ??????? ?????? ????? ?????????? ?????? ????????? ??? ???????? ???????? ??????? ???????? ??? ???????? ??? ???? ????? ???????? ??????? ??????? ?? ??? ??????? ???????????? ??????? ?????? ???? ??????? ????????. ??? ????: ?? ????? ??? ??????? ??? ????? ??????? ???? ?????? ????? ?? ?????? ????? ????? ??????? ????? ?? ??????.
?? ???? ??????? ?????? ?????? ?????????? ???????? ???????? ???? ???????? ?????????? ???????? ???????? ?? ??? ??????? ???????????? ??????? ?????? ???? ??????? ????????? ??? ????? ?????? ????? ??????? ??????? ?????? ?????? ???? ?????? ?????? ?? ????????? ?????????? ?????. ??? ?????? ????? ????? ?????? ?????? ????? ????????? ?????? ???? ??? ??????? ????? ?? ????? ???? ??????.
???? ????? ???????? ???????? ???????? ?? ?????? ??? ????? ?????? ?????? ?????? ??????? ?????????? ????? ??? ????? ?????? ?????? ???????? ??? ??????? ?????? ??? ???????. ??? ??? ????????? ???? ?????? ?????? ?????? ??????? ???????? ??????? ??????? ??????? ?????? ?????? ?????? ?????? ??????? ????? ??????.
?????? ????? ???????: ?????? ????? ??????? (??????) ?? ??????? ??????? ????? ???????? ???????? ???????? ??? ???????. ?? ???? ???????? ?????? ????? ???????? ???? ????????? ??? ??? ??? ??????. ??????? ???????? ??? ??????? ????? ?? ?????? ????? ????? ?? ????? ?????? ?????. ???? ??? ???????? ?????????? ?????? ?????? ?????????? ??? ????? ?? ?????? ?????? ??????? ??? ?????? ????? ????? ?????????? ?????? ???????? ??? ?? ?????? ????????? ?????? in silico ??????????.
????? ??? ????????? ?? ????? ??????? ???????? ?? ?????? ?????? ?????? ???? ??????? ???????? ?????? ??? ?????? ????? ?????? ????? ????? ?????? ????? ??????? ????? ????? ?? ????? ????? ?????? ?????? ?????.